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Asciminib: first FDA approved allosteric inhibitor of BCR-ABL1 for the treatment of chronic myeloid leukemia Surya K. De Review Article 02 February 2023 Pages: 424 - 433
New tetracyclic systems integrated thienopyridine scaffold as an anti-dementia lead: in silico study and biological screening Zeinab MahmoudLamia W. MohamedAfaf El-Malah Original Research Open access 01 February 2023 Pages: 571 - 586
Design, synthesis and anti-TB and anti-bacterial activity of Ciprofloxacin derivatives containing N-(amino)piperazine moieties Xiaoyu QinBin JiangKai Lv Original Research 31 January 2023 Pages: 556 - 570
Novel benzenesulfonamide bearing 1,2,4-triazoles as potent anti-microbial and anti-oxidant agents ChanderMonikaSita Ram Original Research 30 January 2023 Pages: 542 - 555
Memantine derived compounds as potent in vitro inhibitors of urease: Repurposing of memantine, sonication assisted derivatization and in vitro enzyme inhibition, kinetics and molecular docking studies Waseem ShehzadMajid KhanM. Iqbal Choudhary Original Research 27 January 2023 Pages: 525 - 541
Medicinal uses, phytochemistry, pharmacology, and taxonomy of Poygonum aviculare L.: a comprehensive review Kaoutar BenrahouMounia DriouechMy El Abbes Faouzi Review Article 25 January 2023 Pages: 409 - 423
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Mannose: a potential saccharide candidate in disease management M. DhanalakshmiD. SruthiJayashankar Das Review Article 20 January 2023 Pages: 391 - 408
α-Glucosidase and cholinesterase inhibiting potential of a series of semisynthetic nitrogen triterpenic derivatives Oxana KazakovaIrina SmirnovaRené Csuk Original Research 19 January 2023 Pages: 485 - 494
Novel vitamin K3 analogs containing 3-N-substituted aromatic and piperazine rings with selective in vitro anticancer activity against HeLa, U87 MG, and MCF-7 cells Aesha F. S. H. AbdassalamNahide Gulsah DenizNazli Arda Original Research 18 January 2023 Pages: 475 - 484
Engelheptanoxides behave as liver X receptor α agonists Yu-Hsuan LiangYu-Han LuoHsiang-Ru Lin Brief Report 13 January 2023 Pages: 434 - 441
Rational design and development of novel NAE inhibitors for the treatment of pancreatic cancer Cheng LuPeng LuYubin Wang Original Research 12 January 2023 Pages: 442 - 474
Correction: Design, synthesis, and antimicrobial evaluation of novel 10-Undecenoic acid-based lipidic triazoles B. GandhiK. GreeshmaShiva Shanker Kaki Correction 04 January 2023 Pages: 390 - 390
Novel fluorinated pyrazole-based heterocycles scaffold: cytotoxicity, in silico studies and molecular modelling targeting double mutant EGFR L858R/T790M as antiproliferative and apoptotic agents Eman A. FayedNirvana A. GoharYousry A. Ammar Original Research Open access 02 January 2023 Pages: 369 - 388
Design, synthesis and evaluation of salicylic acid-donepezil hybrids as functional agents for the treatment of Alzheimer’s disease Ying HeZhili RaoZhipei Sang Original Research 02 January 2023 Pages: 355 - 368
Synthesis and bioactivity evaluation of pachymic acid derivatives as potential cytotoxic agents Hezhen WangXun SunLei Zhang Original Research 29 December 2022 Pages: 342 - 354
Evaluation of a series of nucleoside analogs as effective anticoronaviral-2 drugs against the Omicron-B.1.1.529/BA.2 subvariant: A repurposing research study Amgad M. RabieMohnad Abdalla Original Research Open access 29 December 2022 Pages: 326 - 341
Synthesis, biological evaluation, and molecular modeling studies of a new series of imidazothiazole or imidazooxazole derivatives as inhibitors of ectonucleoside triphosphate diphosphohydrolases (NTPDases) Mahmoud K. ShehataMuhammad UzairMohammed I. El–Gamal Original Research 27 December 2022 Pages: 314 - 325
Study on structure-activity relationship (SAR) of simplified mirogabalin derivatives as voltage-gated calcium channel α2δ ligands for the treatment of chronic neuropathic pain Yuanwen ZhangYueming ZhengHuihui Ti Original Research 26 December 2022 Pages: 288 - 313
A Click Synthesis, Molecular Docking and Biological Evaluation of 1,2,3-triazoles-benzoxazepine hybrid as potential anticancer agents Muhammad AshramAlmeqdad Y. HabashnehMutasem O. Taha Original Research 26 December 2022 Pages: 271 - 287
Glycosylated triptolide affords a potent in vivo therapeutic activity to hepatocellular carcinoma in mouse model Jian XueFeng PanFrank Shujie Hou Original Research 26 December 2022 Pages: 254 - 270
Correction: Novel Curcumin Monocarbonyl Analogue-Dithiocarbamate hybrid molecules target human DNA ligase I and show improved activity against colon cancer Deependra K. SinghDhanaraju MandalapuDibyendu Banerjee Correction 24 December 2022 Pages: 389 - 389
Evaluation of antibacterial, antioxidant, cytotoxic, and acetylcholinesterase inhibition activities of novel [1,4] benzoxazepines fused to heterocyclic systems with a molecular modeling study Ahmed Al-MustafaWael Al-ZereiniMahmoud A. Al-Sha’er Original Research 24 December 2022 Pages: 239 - 253
Design, synthesis, and biological evaluation of dual-target COX-2/5-LOX inhibitors for the treatment of inflammation Le DuShuaishuai DuHongwei Wang Original Research 23 December 2022 Pages: 218 - 238
Tetra-substituted pyrazole analogues: synthesis, molecular docking, ADMET prediction, antioxidant and pancreatic lipase inhibitory activities Adnan CetinAli DonmezIshak Bildirici Original Research 22 December 2022 Pages: 189 - 204
Optimization of the dipeptide motifs in the PSMA ligands linker structure: synthesis and in vitro evaluation Anastasiia A. UspenskayaEkaterina A. NimenkoAleksei E. Machulkin Brief Report 21 December 2022 Pages: 32 - 37
2,3-Diketopiperazine as potential scaffold to develop new anti-Chagasic agents Urbano Osorio-NietoCristian O. SalasChristian Espinosa-Bustos Original Research 16 December 2022 Pages: 176 - 188
Dipeptidyl Peptidase-IV Blockers Potently Inhibit Monoglyceride Lipase: Investigation By Docking Studies And In Vitro Bioassay Dania AlkabbaniLina A. DahabiyehMutasem O. Taha Original Research 14 December 2022 Pages: 165 - 175
1,2,3-triazenes and 1,2,3-triazoles as antileishmanial, antitrypanosomal, and antiplasmodial agents Insa SeckIsmaïla CissMatar Seck Original Research 10 December 2022 Pages: 158 - 164
Synthesis and cytotoxic/antimicrobial screening of 2-alkenylimidazo[1,2-a]pyrimidines Ángel Ramírez-TrinidadKarol Carrillo-JaimesEduardo Hernández-Vázquez Original Research 09 December 2022 Pages: 144 - 157
Synthesis, pharmacological and molecular docking investigations of 1,3,4-oxadiazole-5-thionyl derivatives of extracted cis-clerodane diterpenoid from Cistus monspeliensis Fatima I. MahiMohammed A. MehdidRachid Chahboun Original Research 01 December 2022 Pages: 128 - 143
Design, synthesis, and biological evaluation of 2, 4-dichlorophenoxyacetamide chalcone hybrids as potential c-Met kinase inhibitors Heena BhojwaniSanskruti PatilParul Bedi Original Research 24 November 2022 Pages: 109 - 127
Design, synthesis and anticancer activity studies of novel indole derivatives as Bcl-2/Mcl-1 dual inhibitors Yingfei LiuJianjun LiTingting Liu Original Research 18 November 2022 Pages: 99 - 108
Synthesis, antimicrobial, and antioxidant activities of disubstituted 1,2,3-triazoles with amide-hydroxyl functionality Manisha ChahalChander Prakash KaushikAshwani Kumar Original Research 17 November 2022 Pages: 85 - 98
Synthesis of myricetin derivatives and evaluation of their hypoglycemic activities Feng LiChong YangWenbao Li Original Research 10 November 2022 Pages: 76 - 84
A study from structural insight to the antiamyloidogenic and antioxidant activities of flavonoids: scaffold for future therapeutics of Alzheimer’s disease Madhu Sudan Dutta Review Article 09 November 2022 Pages: 15 - 31
Novel Curcumin Monocarbonyl Analogue-Dithiocarbamate hybrid molecules target human DNA ligase I and show improved activity against colon cancer Deependra K. SinghDhanaraju MandalapuDibyendu Banerjee Original Research 05 November 2022 Pages: 57 - 75
Synthesis and in vitro antimicrobial evaluation of benzothiazolylindenopyrazoles Satbir MorMohini KhatriKomal Jakhar Original Research 01 November 2022 Pages: 47 - 56
Optimization of clofibrate with natural product sesamol for reducing liver injury induced by acetaminophen Chuchu HanLinyang ZhangYing Liu Original Research 01 November 2022 Pages: 38 - 46
Medicinal chemistry insights into non-hydroxamate HDAC6 selective inhibitors FaridoonYuqi Lavender ZhaJie Jack Li Review Article 31 October 2022 Pages: 1 - 14
An in vitro study of the 5-methyl- and 5-bromo/chloro substituted 2-hydroxy-3-nitrochalcones as α-glucosidase and/or α-amylase inhibitors with potential anti-inflammatory activity Malose J. MphahleleMarole M. MalulekaVusi G. Mbazima Original Research 27 October 2022 Pages: 2243 - 2259
In vitro antiproliferative activity of Parrotia persica exclusive gallotannin Mohammad Hossein RezadoostHassan Hassani KumlehFrank Surup Original Research 27 October 2022 Pages: 205 - 217
Biological evaluation of imidazopyridine derivatives as potential anticancer agents against breast cancer cells Bilgesu Onur Sucu Original Research 26 October 2022 Pages: 2231 - 2242
Clotrimazole-based hybrid structures of pyrazole and benzimidazole: synthesis, antifungal evaluation and computational studies Leila EmamiZeinab FaghihSoghra Khabnadideh Original Research 25 October 2022 Pages: 2220 - 2230
Effect of a hexacyclic triterpenic acid from Euscaphis japonica on the oleic acid induced HepG2 cellular model of non-alcoholic fatty liver disease Yu ChenShaojun ZhangZhengzhi Wu Original Research 20 October 2022 Pages: 2209 - 2219
The potential of chalcone derivatives as human carbonic anhydrase inhibitors in the therapy of glaucoma Valentina GocićAna MarkovićJelena Lazarević Review Article 20 October 2022 Pages: 2103 - 2118
Enhanced biological activity of Curcumin Cinnamates: an experimental and computational analysis Nishi Gandha GogoiAziza RahmanJyotirekha G. Handique Original Research 11 October 2022 Pages: 2195 - 2208
