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Laron Syndrome - From Man to Mouse

Lessons from Clinical and Experimental Experience

  • Book
  • © 2011

Overview

Editors:
  1. Zvi Laron

    1. Endocrinology & Diabetes Research Unit, Schneider Children's Hospital, Petah Tikva, Israel

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    You can also search for this editor in PubMed   Google Scholar

  2. J. Kopchick

    1. Edison Biotechnology Institute, Ohio University, Athens, USA

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    You can also search for this editor in PubMed   Google Scholar

  • First book covering this interesting topic, written by Zvi Laron who first described and reported the condition in 1966 (this syndrome is named after him)

  • Describes the comprehensive pathophysiology of IGF-I deficiency and gives valuable advice for the IGF-I treatment

  • Compares IGF-I and GH deficiency and illustrates the effects of the treatment, e.g. metabolic effects, adipose tissue alterations and the effects on aging

  • Includes supplementary material: sn.pub/extras

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Table of contents (59 chapters)

  1. Front Matter

    Pages i-xiv
    Download chapter PDF

  2. Clinical Aspects

    1. Front Matter

      Pages 1-1
      Download chapter PDF

    2. History of the Israeli Cohort of Laron Syndrome Patients (1958–2009)

      • Zvi Laron
      Pages 3-7

    3. Early Investigations: Characterizations of the Circulating Growth Hormone

      • Zvi Laron
      Pages 9-19

    4. Clinical Evidence of Growth Hormone Resistance in Patients with Laron Syndrome

      • Zvi Laron
      Pages 21-25

    5. Diagnosis of Laron Syndrome

      • Zvi Laron
      Pages 27-28

    6. Genetic Aspects

      • Orit Shevah, Zvi Laron
      Pages 29-52

    7. Clinical Evaluation

      • Zvi Laron
      Pages 53-57

    8. Perinatal Development in Laron Syndrome

      • Zvi Laron, Rivka Kauli
      Pages 59-62

    9. Linear Growth Pattern of Untreated Laron Syndrome Patients

      • Zvi Laron, Rivka Kauli
      Pages 63-89

    10. Head Shape, Size, and Growth of Untreated Patients with Laron Syndrome

      • Zvi Laron, Rivka Kauli
      Pages 91-100

    11. Sexual Development in Patients with Laron Syndrome

      • Zvi Laron, Rivka Kauli
      Pages 101-118

    12. Sex Hormone Binding Proteins and Sex Hormones in Untreated and IGF-I Treated Patients with Laron Syndrome

      • Zvi Laron, Rivka Kauli
      Pages 119-123

    13. The Adipose Tissue in Patients with Laron Syndrome

      • Zvi Laron
      Pages 125-134

    14. Investigations to Determine the Cause of Obesity in Patients with Laron Syndrome

      • Zvi Laron, Shira Ginsberg, Nahum Vaisman
      Pages 135-142

    15. Nonalcoholic Fatty Liver Disease (Nafld) in Patients with Laron Syndrome

      • Zvi Laron
      Pages 143-147

    16. Serum Lipids in Patients with Laron Syndrome

      • Zvi Laron
      Pages 149-155

    17. Adiponectin and Leptin in Laron Syndrome

      • Zvi Laron, Hannah Kanety
      Pages 157-160

    18. Muscle Force and Endurance in Untreated Adult and IGF-I Treated Children with Laron Syndrome

      • Zvi Laron
      Pages 161-164

    19. Bone Mineral Density in Untreated and IGF-I or Alendronate-Treated Patients with Laron Syndrome

      • Zvi Laron
      Pages 165-169
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Keywords

About this book

Laron syndrome (LS), or primary growth hormone (GH) insensitivity, was first described in 1966. Since then, many patients worldwide have been diagnosed with LS, which involves defects in the GH receptor that cause combined congenital deficiency of GH and IGF-I activities. In this comprehensive book the authors draw upon 50 years of multidisciplinary clinical and investigative follow-up of the large Israeli cohort of LS patients. The genetic basis of the syndrome is fully considered, and all aspects of the pathophysiology of IGF-I deficiency are described. Data derived from the recently generated mouse model of LS are reviewed and compared with the human LS experience. Valuable advice is provided on treatment, and treatment effects, such as metabolic effects, adipose tissue alterations, and impact on aging, are fully explored. Together, this book condenses, consolidates, compares, and contrasts data derived from the human and mouse LS experiences and provides a unique resource for clinical and basic scientists to evaluate and compare IGF-I and GH actions.

Editors and Affiliations

  • Endocrinology & Diabetes Research Unit, Schneider Children's Hospital, Petah Tikva, Israel

    Zvi Laron

  • Edison Biotechnology Institute, Ohio University, Athens, USA

    J. Kopchick

Bibliographic Information

  • Book Title: Laron Syndrome - From Man to Mouse

  • Book Subtitle: Lessons from Clinical and Experimental Experience

  • Editors: Zvi Laron, J. Kopchick

  • DOI: https://doi.org/10.1007/978-3-642-11183-9

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Medicine, Medicine (R0)

  • Copyright Information: Springer-Verlag Berlin Heidelberg 2011

  • Hardcover ISBN: 978-3-642-11182-2Due: 16 December 2010

  • Softcover ISBN: 978-3-662-50171-9Published: 23 August 2016

  • eBook ISBN: 978-3-642-11183-9Published: 25 November 2010

  • Edition Number: 1

  • Number of Pages: XIV, 531

  • Topics: Pediatrics, Endocrinology, Internal Medicine, Human Genetics, Molecular Medicine, Human Physiology

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